There are echoes of The Great Gatsby when Jack visits Will's well-to-do parents, and the spirit of Scott Fitzgerald continues to resonate through the domestic scenes between Will and Alex and also in the sheer elegance of Edmund White's slightly 'retro' prose style. The first and third parts of this story are written in the third person from Jack's viewpoint. The middle part is narrated by Will as he goes through a crisis, torn between loyalty to his cool WASP wife and a hot new Italian mistress.
It's something of an achievement to write a sympathetic portrait of two men who aren't very sympathetic individuals, indeed not very likeable. Beyond his endless teenage crush on Will, Jack is a total hedonist, incapable of offering anything more than sex and sensation to his many partners. Will is stuffy and conservative (and a Catholic) but he cheats readily and cold-heartedly on the wife he claims to cherish. This is a stylish novel but not a comfortable read. The sex scenes, gay and straight, are graphic and almost clinical.
The theme of this book clearly harks back to Gore Vidal's The City and the Pillar, which must have been the first novel to deal with a gay man's passion for an off-limits friend. White avoids the melodrama with which Vidal chose to climax his story (in both versions). In fact the last chapters of Jack Holmes and his Friend have a lightness of tone that works brilliantly. Friendship comes to seem more important than sex.
I suppose this has to be tagged Gay Fiction. But more than an exemplar of gay fiction, this is among the finest writing I've seen in recent years.